Product Name: Kv3.2
Product Number: AB-NN283-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Potassium voltage-gated channel subfamily C member 2
Target Alias: Kcnc2; KSHIIIA
Product Type Specific: Potassium channel pan-specific antibody
Antibody Code: NN283-1
Antibody Target Type: Pan-specific
Protein UniProt: Q96PR1
Protein SigNET: Q96PR1
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 474-613 (Cytoplasmic C-terminus) of rat Kv3.2a
Production Method: Protein G purified
Target Alias: Kcnc2; KSHIIIA
Product Type Specific: Potassium channel pan-specific antibody
Antibody Code: NN283-1
Antibody Target Type: Pan-specific
Protein UniProt: Q96PR1
Protein SigNET: Q96PR1
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG1
Antibody Immunogen Source: Fusion protein amino acids 474-613 (Cytoplasmic C-terminus) of rat Kv3.2a
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.1% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: In mouse brain lysates, this antibody detects a ~80-100 kDa protein in cell and tissue lysates by Western blotting. Varies due to post-translational modifications.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: A 1:100 dilution of SMC-492 was sufficient for detection of Kv3.2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: Kv3.1 pan-specific antibody (Cat. No.: AB-NN282-1)
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: A 1:100 dilution of SMC-492 was sufficient for detection of Kv3.2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Antibody Specificity: Very high
Related Product 1: Kv3.1 pan-specific antibody (Cat. No.: AB-NN282-1)
Scientific Background: Kv3.2, a member of the KCNC2 gene family, belongs to a group of potassium channels that contribute to the maintenance of cell volume, membrane potential, neuronal excitability and the secretion of transmitters, salt and hormones. Kv3.2 are predominantly expressed in neurons that fire at high frequencies, and in the fast spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus (1-3). They specifically functioning as a delayed rectifier activated by large membrane depolarizations (2, 4).
References
[1] Kolodin Y.O. (2008) http://ykolodin.50webs.com/
[2] Rudy B., McBain C.J. (2001) Trends Neurosci. 24(9): 517-526.
[3] Gutman G.A. et al. (2005) Pharmacol Rev. 57(4): 472-50
[4] Rudy B et al. (1999) Ann. NY Acad. Sci. 868: 304-343.
[1] Kolodin Y.O. (2008) http://ykolodin.50webs.com/
[2] Rudy B., McBain C.J. (2001) Trends Neurosci. 24(9): 517-526.
[3] Gutman G.A. et al. (2005) Pharmacol Rev. 57(4): 472-50
[4] Rudy B et al. (1999) Ann. NY Acad. Sci. 868: 304-343.
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