Product Name: TrpV3
Product Number: AB-NN353-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Transient receptor potential cation channel subfamily V member 3
Target Alias: 1110036I10Rik; MGC124324; MGC124325; TrpV3; Trpv3 heat sensitive channel; TRPV3_HUMAN; Vanilloid receptor 3; Vanilloid receptor like 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; VRL 3;VRL-3; VRL3
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN353-1
Antibody Target Type: Pan-specific
Protein UniProt: Q8NET8
Protein SigNET: Q8NET8
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Target Alias: 1110036I10Rik; MGC124324; MGC124325; TrpV3; Trpv3 heat sensitive channel; TRPV3_HUMAN; Vanilloid receptor 3; Vanilloid receptor like 3; Vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein; VRL 3;VRL-3; VRL3
Product Type Specific: Calcium channel pan-specific antibody
Antibody Code: NN353-1
Antibody Target Type: Pan-specific
Protein UniProt: Q8NET8
Protein SigNET: Q8NET8
Antibody Type: Monoclonal
Antibody Host Species: Mouse
Antibody Ig Isotype Clone: IgG2a
Antibody Immunogen Source: Synthetic peptide amino acids 774-791 (C-terminus) of rat TrpV3
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Antibody Immunogen Source: Synthetic peptide amino acids 774-791 (C-terminus) of rat TrpV3
Production Method: Protein G purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | Immunohistochemistry | ICC/Immunofluorescence | Immunoprecipitation
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~70 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-319 was sufficient for detection of TrpV3 in 10 µg of COS-1 cell lysate transiently transfected with TrpV3 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Related Product 1: TrpC5 pan-specific antibody (Cat. No.: AB-NN350-1)
Antibody Dilution Recommended: WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects a ~70 kDa protein in cell and tissue lysates by Western blotting.
Antibody Species Reactivity: Human | Mouse | Rat
Antibody Positive Control: 1 µg/ml of SMC-319 was sufficient for detection of TrpV3 in 10 µg of COS-1 cell lysate transiently transfected with TrpV3 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Related Product 1: TrpC5 pan-specific antibody (Cat. No.: AB-NN350-1)
Related Product 2: TrpC7 pan-specific antibody (Cat. No.: AB-NN351-1)
Related Product 3: TrpM7 pan-specific antibody (Cat. No.: AB-NK305-1)
Related Product 3: TrpM7 pan-specific antibody (Cat. No.: AB-NK305-1)
Scientific Background: The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels (1, 2).
References
[1] Masamoto Y., Kawabata F., Fushiki T. (2009) Biosci. Biotechnol. Biochem. 73(5): 1021-1027.
[2] Xiao R. et al. (2008) J Biol Chem. 283(10): 6162-6174.
[1] Masamoto Y., Kawabata F., Fushiki T. (2009) Biosci. Biotechnol. Biochem. 73(5): 1021-1027.
[2] Xiao R. et al. (2008) J Biol Chem. 283(10): 6162-6174.
© Kinexus Bioinformatics Corporation 2017