Product Name: UT-A1
Product Number: AB-NN355-1
| Size: | 25 µg | Price: | 89.00 | |
| $US |
Target Full Name: Urea transporter 2
Target Alias: SLC14A2; FLJ16167; hUT-A6; HUT2; kidney; MGC119566; MGC119567; Slc14a2; Solute carrier family 14 (urea transporter); member 2; Solute carrier family 14 member 2; Urea transporter; Urea transporter kidney; UT-A2; UT2; UT2_HUMAN; UTA; UTR; UT1; UTA1
Product Type Specific: Solute carrier protein pan-specific antibody
Antibody Code: NN355-1
Antibody Target Type: Pan-specific
Protein UniProt: Q15849
Protein SigNET: Q15849
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Target Alias: SLC14A2; FLJ16167; hUT-A6; HUT2; kidney; MGC119566; MGC119567; Slc14a2; Solute carrier family 14 (urea transporter); member 2; Solute carrier family 14 member 2; Urea transporter; Urea transporter kidney; UT-A2; UT2; UT2_HUMAN; UTA; UTR; UT1; UTA1
Product Type Specific: Solute carrier protein pan-specific antibody
Antibody Code: NN355-1
Antibody Target Type: Pan-specific
Protein UniProt: Q15849
Protein SigNET: Q15849
Antibody Type: Polyclonal
Antibody Host Species: Rabbit
Antibody Ig Isotype Clone: N/A
Antibody Immunogen Source: Produced against a synthetic peptide mapped to the C-terminal tail (amino acids 911-929) of rat UT-A1 (antibody designation L194)
Production Method: Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence
Production Method: Affinity purified
Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.
Antibody Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide
Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence
Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.
Antibody Potency: Detects ~97 and 127 kDa proteins.
Antibody Species Reactivity: Rat | Mouse
Antibody Positive Control: 1 µg/ml of SPC-406 was sufficient for detection of UT-A1 in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody Potency: Detects ~97 and 127 kDa proteins.
Antibody Species Reactivity: Rat | Mouse
Antibody Positive Control: 1 µg/ml of SPC-406 was sufficient for detection of UT-A1 in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Scientific Background: UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2) (1, 2).
References
[1] Nielsen S. et al. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500.
[2] Smith C.P. (2009) Exp Physiol. 94(2): 180-185.
[1] Nielsen S. et al. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500.
[2] Smith C.P. (2009) Exp Physiol. 94(2): 180-185.
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