Product Name: Alpha-2C Adrenergic Receptor
Product Number: AB-NN371-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Alpha-2C adrenergic receptor

Target Alias: Adra 2c; Alpha-2CAR; ADRA2C; ADRA2L2; ADRARL2; Alpha 2CAR; alpha2 AR C4; alpha2 C4; alpha2C; ALPHA2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor; Adrenergic alpha 2C receptor; Alpha 2C adrenergic receptor subtype C4; Alpha 2C adrenoceptor; Alpha 2C adrenoreceptor; Alpha-2-adrenergic receptor; renal type; alpha2cii-adrenergic receptor; Subtype alpha2 C4

Product Type Specific: G protein-coupled receptor pan-specific antibody

Antibody Code: NN371-1

Antibody Target Type: Pan-specific

Protein UniProt: P18825

Protein SigNET: P18825

Antibody Type: Monoclonal

Antibody Host Species: Mouse

Antibody Ig Isotype Clone: IgG2A

Antibody Immunogen Source: Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor

Production Method: Protein G purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline pH7.4, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.
Product Use: Western blotting | ICC/Immunofluorescence

Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.

Antibody Potency: In mouse brain lysates, this antibody detects a ~50 kDa protein or larger (possibly due to dimerization).

Antibody Species Reactivity: Human | Mouse

Antibody Positive Control: 1 µg/ml of SMC-433 was sufficient for detection of Alpha-2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha-2Cmembrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Antibody Specificity: Very high

Antibody Cross Reactivity: Does not cross-react with other adrenergic receptors.

Scientific Background: The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.