Product Name: Beclin 2 (BECN1L1)
Product Number: AB-NN372-1
Size: 25 µg      Price:89.00
      $US
Target Full Name: Beclin-1-like protein 1

Target Alias: BECN1P1; Beclin-1 autophagy-related pseudogene 1; BECN2; Beclin-2; BECN1L1; Becn2; Beclin-2; PFM 2; PR domain zinc finger protein 5; PRDM 5; PR domain-containing protein 5; PRDM5; PRDM5_HUMAN; PR domain containing protein 5; BCS2

Product Type Specific: Autophagy protein pan-specific antibody

Antibody Code: NN372-1

Antibody Target Type: Pan-specific

Protein UniProt: A8MW95

Protein SigNET: A8MW95

Antibody Type: Polyclonal

Antibody Host Species: Rabbit

Antibody Immunogen Source: Synthetic peptide from the C-terminal of Human Beclin 2 (AA 338-349)

Production Method: Peptide Affinity purified

Antibody Modification: Unconjugated. Contact KInexus if you are interest in having the antibody biotinylated or coupled with fluorescent dyes.

Antibody Concentration: 1 mg/ml

Storage Buffer: Phosphate buffered saline, 50% glycerol, 0.09% sodium azide

Storage Conditions: For long term storage, keep frozen at -40°C or lower. Stock solution can be kept at +4°C for more than 3 months. Avoid repeated freeze-thaw cycles.

Product Use: Western blotting

Antibody Dilution Recommended: WB (1:1000); optimal dilutions for assays should be determined by the user.

Antibody Potency: Detects a weak ~48 kDa protein band in mouse brain lysates by Western blotting.

Antibody Species Reactivity: Human | Rat

Antibody Positive Control: A 1:1000 dilution of SPC-603 was sufficient for detection of Beclin 2 in 15 µg of Human HeLa cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Antibody Specificity: High

Antibody Cross Reactivity: No other prominent cross-reactive proteins in mouse brain lysates.

Related Product 1: Beclin 2 (BECN1L1) pan-specific antibody (Cat. No.: AB-NN372-2)

Scientific Background: Beclin 2 is a novel coiled-coil protein related to the autophagic Beclin 1 protein. It is thought to interact with Bcl-2, an anti-apoptotic protein, and is believed to function in autophagy. It has alson been found to mediate G protein-coupled receptro (GPCR) degradation (1).