Product Name: AQP2 (250-271) T269S
Product Number: PE-01AAM90
Size: 200 µg      Price:62.00
1 mg      $US123.00
5 mg      290.00
Peptide Name: AQP2 (250-271) T269S

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Sus scrofa

Peptide Sequence: EVRRRQSVELHSPQSLPRGSKA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Free carboxyl

Peptide Molecular Mass Calculated: 2517.7 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: Studies reveal a reciprocal change in Ser-256 and Ser-261 phosphorylation in response to short-term vasopressin exposure, indicating that these residues may serve distinct roles in regulation of AQP2 subcellular distribution and collecting duct water permeability.
References

[1] Christensen BM, Zelenina M, Aperia A, Nielsen S. Localization and regulation of PKA-phosphorylated AQP2 in response to V(2)-receptor agonist/antagonist treatment. Localization and regulation of PKA-phosphorylated AQP2 in response to V(2)-receptor agonist/antagonist treatment. Am J Physiol Renal Physiol. 2000 Jan;278(1):F29-42. PMID: 10644653.

[2] Hoffert JD, Nielsen J, Yu MJ, Pisitkun T, Schleicher SM, Nielsen S, Knepper MA. Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Am J Physiol Renal Physiol. 2007 Feb;292(2):F691-700. Epub 2006 Sep 19. PMID: 16985212.

[3] Ward DT, Hammond TG, Harris HW. Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles. Annu Rev Physiol. 1999;61:683-97. PMID: 10099706.