Product Name: GluR2 (844-858) del 849-853
Product Number: PE-01ABL90
Size: 200 µg      Price:28.00
1 mg      $US56.00
5 mg      132.00
Peptide Name: GluR2 (844-858) del 849-853

Product Use: Peptide disrupts AP2 but not NSF binding and prevents AMPA receptor endocytosis and LTD without affecting basal synaptic transmission. The peptide sequence is located in the C-terminus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: KRMKLNINPS

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1199.5 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: GLuR2 is a receptor for the excitatory neurotransmitter L-glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. Binding of L-glutamate induces a conformation change, leading to the opening of the cation channel, and to generate an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.