Product Name: Autocamtide-2 peptide
Product Number: PE-01ACM95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 83.00 | ||
| 5 mg | 182.00 |
Peptide Name: Autocamtide-2 peptide
Product Use: For assaying the phosphotransferase activities of PNCK pregnancy up-regulated non-ubiquitously expressed CaM kinase (CAMK1b, UniProt ID Q6P2M8), Calcium/calmodulin-dependent protein kinase type I delta (CAMK1d, UniProt ID Q8IU85), Calcium/calmodulin-dependent protein-serine kinase 2 alpha (CaMK2a, UniProt ID Q9UQM7), Calcium-calmodulin-dependent protein kinase type II beta chain (CAMK2b, UniProt ID Q13554), Calcium-calmodulin-dependent protein kinase type II gamma chain (CAMK2g, UniProt ID Q13555), Calcium-calmodulin-dependent protein kinase type II delta chain (CAMK2d, UniProt ID Q13557), and Calcium-calmodulin-dependent protein kinase type IV (CAMK4, UniProt ID Q16566).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on autophosphorylation site in CaMK isoforms that confers calcium-independent catalytic activity
Product Use: For assaying the phosphotransferase activities of PNCK pregnancy up-regulated non-ubiquitously expressed CaM kinase (CAMK1b, UniProt ID Q6P2M8), Calcium/calmodulin-dependent protein kinase type I delta (CAMK1d, UniProt ID Q8IU85), Calcium/calmodulin-dependent protein-serine kinase 2 alpha (CaMK2a, UniProt ID Q9UQM7), Calcium-calmodulin-dependent protein kinase type II beta chain (CAMK2b, UniProt ID Q13554), Calcium-calmodulin-dependent protein kinase type II gamma chain (CAMK2g, UniProt ID Q13555), Calcium-calmodulin-dependent protein kinase type II delta chain (CAMK2d, UniProt ID Q13557), and Calcium-calmodulin-dependent protein kinase type IV (CAMK4, UniProt ID Q16566).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on autophosphorylation site in CaMK isoforms that confers calcium-independent catalytic activity
Peptide Sequence: KKALRRQETVDAL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1527.7 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: CAMK1; CAMK1b; CAMK1d; CAMK1g; CAMK2a; CAMK2b; CAMK1g; CAMK1d; CAMK4
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1527.7 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: CAMK1; CAMK1b; CAMK1d; CAMK1g; CAMK2a; CAMK2b; CAMK1g; CAMK1d; CAMK4
Scientific Background: CaMK2a is a protein-serine/threonine kinase of the CAMK group and CAMK2 family. It is a calcium/calmodulin-activated protein kinase involved in neurotransmitter release and long term potentiation in neurons. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state
References
[1] Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science. 1992 Jul 10;257(5067):206-11. PMID: 1321493.
[2] Thiagarajan TC, Piedras-Renteria ES, Tsien RW. alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron. 2002 Dec 19;36(6):1103-14. PMID: 12495625.
[1] Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science. 1992 Jul 10;257(5067):206-11. PMID: 1321493.
[2] Thiagarajan TC, Piedras-Renteria ES, Tsien RW. alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron. 2002 Dec 19;36(6):1103-14. PMID: 12495625.
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