Product Name: CREB1 (123-135) KinSub
Product Number: PE-01ACP95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 83.00 |
Peptide Name: CREB1 (123-135) KinSub
Product Use: For assaying the phosphotransferase activities of PNCK pregnancy up-regulated non-ubiquitously expressed CaM kinase (CAMK1b, UniProt ID Q6P2M8), Calcium/calmodulin-dependent protein kinase type I delta (CAMK1d, UniProt ID Q8IU85), Calcium/calmodulin-dependent protein kinase type I gamma (CAMK1g, UniProt ID Q96NX5), Calcium-calmodulin-dependent protein kinase type IV (CAMK4, UniProt ID Q16566), and protein kinase C-alpha (PKCa, UniProt ID P17252).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on phosphosite in CREB transcription factor
Peptide Sequence: KRREILSRRPSYR
Peptide Modifications N Terminus: Free amino
Product Use: For assaying the phosphotransferase activities of PNCK pregnancy up-regulated non-ubiquitously expressed CaM kinase (CAMK1b, UniProt ID Q6P2M8), Calcium/calmodulin-dependent protein kinase type I delta (CAMK1d, UniProt ID Q8IU85), Calcium/calmodulin-dependent protein kinase type I gamma (CAMK1g, UniProt ID Q96NX5), Calcium-calmodulin-dependent protein kinase type IV (CAMK4, UniProt ID Q16566), and protein kinase C-alpha (PKCa, UniProt ID P17252).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on phosphosite in CREB transcription factor
Peptide Sequence: KRREILSRRPSYR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1717 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: PKAca; PKAcb; PKAcg; PKCa; PKCbII; PKCd; PKCi; PKC-mu; PKCv; PKCz; PKD2; CAMK1b; CAMK1d; CAMK1g; CAMK4
Peptide Molecular Mass Calculated: 1717 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: PKAca; PKAcb; PKAcg; PKCa; PKCbII; PKCd; PKCi; PKC-mu; PKCv; PKCz; PKD2; CAMK1b; CAMK1d; CAMK1g; CAMK4
Scientific Background: CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation (1). Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons (2). CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression.
References
[1] Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, Bleckmann S, Gass P, Kretz O, Mitchell JM, Schütz G, Maldonado R. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology. 2004 Jun;29(6):1122-33. PMID: 15029152.
[2] Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schütz G. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54. PMID: 11967539.
[1] Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, Bleckmann S, Gass P, Kretz O, Mitchell JM, Schütz G, Maldonado R. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology. 2004 Jun;29(6):1122-33. PMID: 15029152.
[2] Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schütz G. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May;31(1):47-54. PMID: 11967539.
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