Product Name: PKAIa (15-23) KinSub
Product Number: PE-01ADK95
| Size: | 200 µg | Price: | 32.00 | |
| 1 mg | $US | 64.00 | ||
| 5 mg | 140.00 |
Peptide Name: PKAIa (15-23) KinSub
Product Use: For assaying the phosphotransferase activities of cAMP-dependent protein kinase, alpha-catalytic subunit (PKAa, UniProt ID P17612), RAC-alpha serine-threonine-protein kinase (Akt1, UniProt ID P31749), 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK1a, UniProt ID Q13131), and Ribosomal protein S6 kinase 2 (p70S6Kb, UniProt ID Q9UBS0).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on cAMP-dependent protein kinase inhibitor
Peptide Sequence: CGRTGRRNSI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: For assaying the phosphotransferase activities of cAMP-dependent protein kinase, alpha-catalytic subunit (PKAa, UniProt ID P17612), RAC-alpha serine-threonine-protein kinase (Akt1, UniProt ID P31749), 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK1a, UniProt ID Q13131), and Ribosomal protein S6 kinase 2 (p70S6Kb, UniProt ID Q9UBS0).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Based on cAMP-dependent protein kinase inhibitor
Peptide Sequence: CGRTGRRNSI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1118.4 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Akt2; AMPK (A1/B1/G1); AMPK (A2/B1/G1); p70S6Kb
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Akt2; AMPK (A1/B1/G1); AMPK (A2/B1/G1); p70S6Kb
Scientific Background: Akt1 is one of several kinases that will phosphorylate PKAIa. Human Akt1 is a protein-serine/threonine kinase of 480 amino acid length, with a predicted molecular mass of 55,686 Da. It is a member of the ACG group of protein kinases in the AKT family. This kinase is highly expressed in most tested human tissues. Orthologues of Akt are conserved in a wide range of animals, plants and unicellular eukaryotes. Phosphorylation of Akt1 at Thr-72, Ser-124, Ser-129, Ser-246, Thr-308, Tyr-315, Tyr-326, Thr-450, Ser-473 and Tyr-474 increases its phosphotransferase activity. Akt1 has been implicated in a wide range of human cancers, including lymphomas, breast, lung, colorectal, pancreatic and prostate cancers.
© Kinexus Bioinformatics Corporation 2017