Product Name: A-beta (11-22)
Product Number: PE-01AFB95
Size: 200 µg      Price:38.00
1 mg      $US77.00
5 mg      168.00
Peptide Name: A-beta (11-22)

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: EVHHQKLVFFAE

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Free carboxyl

Peptide Molecular Mass Calculated: 1483.7 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: Simulation results suggest that this peptide is one of 3 sites that may play a crucial role in determining the aggregation tendency and the fibrillar structure of Abeta(42). Increasing evidence implicates interactions between Abeta peptide and lipids in the development of Alzheimer's disease. A study on the 11-22 amphiphilic domain of Abeta which contains most of the charged residues of the N-terminal domain of Abeta suggest that the peptide charge, and more precisely the protonation state of histidines 13 and/or 14, is important for the interaction with lipids.
References

[1] Cecchini M, Curcio R, Pappalardo M, Melki R, Caflisch A. A molecular dynamics approach to the structural characterization of amyloid aggregation. J Mol Biol. 2006 Apr 7;357(4):1306-21. Epub 2006 Jan 26. PMID: 16483608

[2] Ravault S, Flore C, Saurel O, Milon A, Brasseur R, Lins L. Study of the specific lipid binding properties of Abeta 11-22 fragment at endosomal pH. Langmuir. 2009 Sep 15;25(18):10948-53. doi: 10.1021/la901544g. PMID:19735146