Product Name: CLEC16A (141-149)
Product Number: PE-01AGE95
| Size: | 200 µg | Price: | 29.00 | |
| 1 mg | $US | 58.00 |
Peptide Name: CLEC16A (141-149)
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Mus musculus
Peptide Sequence: YYISFLKTL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1146.6 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Mus musculus
Peptide Sequence: YYISFLKTL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1146.6 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: CLEC16A is a C-type lectin domain family member that acts as a modulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. It may protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. It plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. It is almost exclusively expressed in immune cells. Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes CLEC16A.
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