Product Name: KinSub1DDIYV
Product Number: PE-01AGN95
| Size: | 200 µg | Price: | 99.00 | |
| $US |
Peptide Name: KinSub1DDIYV
Product Use: For assaying the phosphotransferase activity of Tyrosine-protein kinase STYK1 (SuRTK,106, UniProt ID Q6J9G0). The KinSub1DDIYV peptide demonstrated very high phosphotransferase activity with Brk, and exhibited medium specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub1DDIYV was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGGEDDIYVGVGGGG
Product Use: For assaying the phosphotransferase activity of Tyrosine-protein kinase STYK1 (SuRTK,106, UniProt ID Q6J9G0). The KinSub1DDIYV peptide demonstrated very high phosphotransferase activity with Brk, and exhibited medium specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub1DDIYV was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGGEDDIYVGVGGGG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1307.3 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Brk
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1307.3 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Brk
Scientific Background: SuRTK106 is one of several protein kinases that can phosphorylate KinSub1DDIYV. Human STYK1 (also known as NOK and SuRTK106) is a protein-tyrosine kinase of 422 amino acid length, with a predicted molecular mass of 47,547 Da. It is a member of the TK group of receptor-protein kinases in the TK-Unique family. STYK1 plays important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (1). STYK1 concomitantly activate both MAP kinase and PI3K pathways in stably transfected mouse pre-B cells and STYK1 expression is elevated in 92.3% cancerous tissues in comparison with normal tissues (2).
References
[1] Liu L, Yu XZ, Li TS, Song LX, Chen PL, Suo TL, Li YH, Wang SD, Chen Y, Ren YM, Zhang SP, Chang ZJ, Fu XY. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Res. 2004 May 15;64(10):3491-9. PMID: 15150103.
[2] Amachika T, Kobayashi D, Moriai R, Tsuji N, Watanabe N. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. Lung Cancer. 2007 Jun;56(3):337-40. PMID: 17298854.
[1] Liu L, Yu XZ, Li TS, Song LX, Chen PL, Suo TL, Li YH, Wang SD, Chen Y, Ren YM, Zhang SP, Chang ZJ, Fu XY. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Res. 2004 May 15;64(10):3491-9. PMID: 15150103.
[2] Amachika T, Kobayashi D, Moriai R, Tsuji N, Watanabe N. Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. Lung Cancer. 2007 Jun;56(3):337-40. PMID: 17298854.
© Kinexus Bioinformatics Corporation 2017