Product Name: KinSub1RRGSF
Product Number: PE-01AJB95
| Size: | 200 µg | Price: | 99.00 | |
| $US |
Peptide Name: KinSub1RRGSF
Product Use: For assaying the phosphotransferase activity of Protein-serine kinase C nu; Serine/threonine-protein kinase D3 (PKD3, UniProt ID O94806). The KinSub1RRGSF peptide demonstrated very high phosphotransferase activity with PAK5 (PAK7), and exhibited moderate specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub1RRGSF was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGLGRRGSFANLGHL
Product Use: For assaying the phosphotransferase activity of Protein-serine kinase C nu; Serine/threonine-protein kinase D3 (PKD3, UniProt ID O94806). The KinSub1RRGSF peptide demonstrated very high phosphotransferase activity with PAK5 (PAK7), and exhibited moderate specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub1RRGSF was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGLGRRGSFANLGHL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1510.7 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: PAK5 (PAK7)
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1510.7 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: PAK5 (PAK7)
Scientific Background: PKD3 is one of several protein kinases that can phosphorylate KinSub1RRGSF. Human PKD3 (also known as PKC-nu and PKCv) is a protein-serine/threonine kinase of 890 amino acid length, with a predicted molecular mass of 100,471 Da. It is a member of the CAMK group of protein kinases in the PKD family (1). The PKD3 gene is located between markers WI-9798 and D2S177 on chromosome 2p21 region. This kinase is highly expressed and widely distributed in most tested human tissues except in the brain and spinal cord where it is poorly expressed. Orthologues of PKD3 are highly conserved in vertebrates and insects. PKD3 is activated by DAG and phorbol esters, which mediates translocation to the cell membrane. PKD3 is also activated by phosphorylation at S731 and S735. PKD3 has been linked with the development of glioblastoma multiforme (GM).
© Kinexus Bioinformatics Corporation 2017