Product Name: KinSub2DDDYF
Product Number: PE-01AJR95
| Size: | 200 µg | Price: | 99.00 | |
| $US |
Peptide Name: KinSub2DDDYF
Product Use: For assaying the phosphotransferase activity of Tyrosine-protein kinase receptor TYRO3 (UniProt ID Q06418). The KinSub2DDDYF peptide demonstrated very high phosphotransferase activity with Brk, and exhibited medium specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub2DDDYF was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGLEDDDYFGPGGGG
Product Use: For assaying the phosphotransferase activity of Tyrosine-protein kinase receptor TYRO3 (UniProt ID Q06418). The KinSub2DDDYF peptide demonstrated very high phosphotransferase activity with Brk, and exhibited medium specificity when assayed with over 200 other protein kinases. A listing of other kinases that show appreciable phosphotransferase activity towards this peptide are listed in Table 1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: KinSub2DDDYF was originally identified using a microarray with peptides that were predicted as optimal substrates for 500 human protein kinases with a proprietary algorithm developed at Kinexus with our academic partners.
Peptide Sequence: GGLEDDDYFGPGGGG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1411.4 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Brk
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1411.4 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Brk
Scientific Background: Tyro3 is a receptor protein-tyrosine kinase of the TK group and Axl family. It responds to TUB, TULP1, GAS6 and protein S as ligands and regulates cell survival, proliferation, immunoregulation, phagocytosis, cell migration, actin organization, spermatogenesis, platelet aggregation, clot stabilization, memory formation, circadian rhythm and synaptic plasticity. This kinase is moderate to highly expressed in most tested human tissues; it is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumour cell lines. Tyro3 interacts with GAS6. Tyro3 together with AXL and MER form the AXL/Tyro3 family of receptor-tyrosine kinases. Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, Tyro3 participates in cell adhesion. Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. Signalling transduction can occur via MAPK/ERK and Pi3K/Akt pathways. Overexpression in various cancers provide transformative ability and increased survival signals. Tyro3 has been linked with the development of mammary cancer and multiple myelomas. Tyro3 may also be a potential therapeutic target in breast cancer.
References
[1] Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts MF, Plaisance S, Collen D, Conway EM, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005 Feb;115(2):237-46. PMID: 15650770 PMCID: PMC544035
[2] Liao X, Zhou R, Gilbert DJ, Copeland NG, Jenkins NA. Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk. Mamm Genome. 1996 May;7(5):395-6. PMID: 8661736
[1] Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts MF, Plaisance S, Collen D, Conway EM, Wehrle-Haller B, Carmeliet P. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest. 2005 Feb;115(2):237-46. PMID: 15650770 PMCID: PMC544035
[2] Liao X, Zhou R, Gilbert DJ, Copeland NG, Jenkins NA. Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk. Mamm Genome. 1996 May;7(5):395-6. PMID: 8661736
© Kinexus Bioinformatics Corporation 2017