Product Name: PF4 (89-101)
Product Number: PE-01ALZ90
Size: 200 µg      Price:36.00
1 mg      $US73.00
Peptide Name: PF4 (89-101)

Product Use: Can be used to make technetium-99m (Tc-99m) labeled peptides that specifically bind to sites of infection, inflammation, thrombosis, atherosclerosis and neoplatic growth in vivo, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: PLYKKIIKKLLES

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1572.3 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: Platelet factor 4, noncovalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4 sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes.The last 13 aa of PF-4 have antibacterial activity
References

[1] Technetium-99m labeled peptides for imaging inflammation; US patent #5552525 A

[2] Technetium-99m labeled peptides for imaging; US patent #5780007;