Product Name: CLEC16A (390-404)
Product Number: PE-01AMC90
Size: 200 µg      Price:42.00
1 mg      $US84.00
5 mg      198.00
Peptide Name: CLEC16A (390-404)

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: RPNYKNVGEEEDEEK

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1835.9 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: CLEC16A is a C-type lectin domain family member that acts as a modulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PARK2 pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. It may protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PARK2. It plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. It is almost exclusively expressed in immune cells. Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes CLEC16A.