Product Name: GluR1 (850-862)
Product Number: PE-01AMJ95
Size: | 200 µg | | Price: | 42.00 |
| 1 mg | | $US | 83.00 |
| 5 mg | | | 182.00 |
Peptide Name: GluR1 (850-862)
Product Use: The peptide sequence is located in the C-terminus of the protein.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: INEAIRTSTLPRN
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1484.83 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: GluR1 is an ionotropic glutamate receptor. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel to genrate an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
References[1] Lee, H-K., Takamiya, K., He, K., Song, L., Huganir, R.L. Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) PhosphorylationSites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus. J Neurophysiol 103: 479–489, 2010.