Product Name: SMG1 (3636-3650)
Product Number: PE-01ATI75
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Peptide Name: SMG1 (3636-3650)
Product Use: Services as a blocking peptide for use with the SMG1-3 rabbit polyclonal antibody (Cat. No.: AB-NK233-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CQVDYVIKEATNLDNL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1838 Da
Peptide Appearance: White powder
Product Use: Services as a blocking peptide for use with the SMG1-3 rabbit polyclonal antibody (Cat. No.: AB-NK233-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CQVDYVIKEATNLDNL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1838 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Tends to dimerize
Related Product 1: SMG1 pan-specific antibody (Cat. No.: AB-NK233-3)
Storage Conditions: -20°C
Storage Stability: Tends to dimerize
Related Product 1: SMG1 pan-specific antibody (Cat. No.: AB-NK233-3)
Scientific Background: SMG1 (ATX) is a protein-serine/threonine kinase of the Atypical group and PIKK family. It mediates the genotoxic stress pathway as well as the mRNA surveillance pathway. SMG1 will target nonsense RNA molecules for degradation via phosphorylation of RENT1/UPF1. SMG1 is essential for optimal phosphorylation and activity of p53/TP53 following genotoxic stress. It is iInhibited by caffeine, LY294002 and wortmannin.
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