Product Name: Fms (303-317)
Product Number: PE-01ATR80
Size: 200 µg      Price:12.00
1 mg      $US23.00
Peptide Name: Fms (303-317)

Product Use: Services as a blocking peptide for use with the CSF1R -3 rabbit polyclonal antibody (Cat. No.: AB-NK234-4) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: CLSSEQNLIQEVTVGE

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1747.9 Da

Peptide Purity Percent after Synthesis and Purification: >50

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: Fms pan-specific antibody (Cat. No.: AB-NK234-4)

Scientific Background: CSF1R (Fms) is a member of the TK group of protein kinases in the PDGFR family. It acts as a membrane receptor for macrophage colony-stimulating factor 1 (CSF1) and IL34, and it functions in the regulation of cell survival, proliferation, and differentiation in hematopoietic precursor cells, specifically monocytes and macrophages. However, this kinase is highly expressed and widely distributed in most tested human tissues except in the brain and spinal cord, where it is more moderately expressed. Orthologues of CSF1R are highly conserved in mammals and birds. CSF1R contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in CSF1R have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy. CSF1R has been linked with the development of acute myeloid leukemia, chronic myelomonocytic leukemia, myelodysplasia, hepatocellular carcinomas, breast cancer, and lung squamous cell carcinomas (LSCC). Gain-of-function mutations in the Fms gene are associated with several forms of cancer.