Product Name: AurC (1-15)
Product Number: PE-01AWY90
Size: 200 µg      Price:38.00
1 mg      $US77.00
5 mg      166.00
Peptide Name: AurC (1-15)

Product Use: Services as a blocking peptide for use with the AurKC-1 rabbit polyclonal antibody (Cat. No.: AB-NK009-2) that is also available from Kinexus. The peptide sequence is located in the N-terminus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens


Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1671.01 Da

Peptide Purity Percent after Synthesis and Purification: >80

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: AurC pan-specific antibody (Cat. No.: AB-NK009-2)

Scientific Background: AurC (AurKC) is a protein-serine/threonine kinase of the Other group and AUR family. It serves an essential component of the chromosomal passenger complex (CPC), which functions to ensure correct chromosomal alignment and segregation during mitosis. In addition, this protein complex is necessary for chromatin-induced microtubule stabilization and formation of the spindle apparatus. AurC has also been shown to play a key role in meiosis, specifically during spermatogenesis (production of sperm). Several mutations in the AurC gene have been observed in male patients with spermatogenic failure 5, including a 1-bp deletion (144delC) leading to premature translation termination at position 71 and a truncated protein without a catalytic domain, a C229Y substitution mutation in the kinase catalytic domain of the protein, and a 2A-to-G transition mutation at the splice site of intron 4 (436-2A-G) leading to the omission of exon 5 from the protein. These mutations result in a loss-of-function for the protein catalytic activity, therefore defects in AurC activity are thought to be the primary contributing factor to the development of spermatogenic failure 5.