Product Name: ERK2 (263-277)
Product Number: PE-01AXE99
| Size: | 200 µg | Price: | 51.00 | |
| 1 mg | $US | 102.00 | ||
| 5 mg | 224.00 |
Peptide Name: ERK2 (263-277)
Product Use: Services as a blocking peptide for use with the ERK2-1 rabbit polyclonal antibody (Cat. No.: AB-NK056-2) that is also available from Kinexus. The peptide sequence is located in the pre-kinase last alpha-chain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CYLLSLPHKNKVPWNR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1967.34 Da
Peptide Purity Percent after Synthesis and Purification: >95
Product Use: Services as a blocking peptide for use with the ERK2-1 rabbit polyclonal antibody (Cat. No.: AB-NK056-2) that is also available from Kinexus. The peptide sequence is located in the pre-kinase last alpha-chain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CYLLSLPHKNKVPWNR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1967.34 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ERK2 pan-specific antibody (Cat. No.: AB-NK056-2)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ERK2 pan-specific antibody (Cat. No.: AB-NK056-2)
Scientific Background: ERK2 (MAPK1) is a protein-serine/threonine kinase of the CMGC group and MAPK family. It is involved in the MAP Kinase signalling pathway. The MAP kinase pathway can mediate cell adhesion, growth, survival, differentiation, meiosis, mitosis, and other post-mitotic functions. Phosphorylation of T185 and Y187 by MEK1 an MEK2 increases its phosphotransferase activity. It phosphorylates many diffrent transcription factors, such as ELK1. It acts as transcriptional repressor by binding directly to DNA. It is essential for cyclin D1 induction. MAPK1 phosphorylates BCL2, which contributes to cell survival, the suppression of the apoptotic effect of BAD and up-regulation of the antiapoptotic protein MCL-1. It regulates accumulation of p53 during DNA damage response. ERK2 appears to be a tumour requiring protein (TRP). The active form of the protein kinase normally acts to promote tumour cell proliferation. ERK2 has been linked with the Ewing's Family of tumours, which are rare cancers that are similar to medullablastoma and cerebral primitive neuroectodermal tumours. It is constitutively active in many human tumours, primarily due to altered Ras, Raf, EGFR or other upstream oncoproteins.
© Kinexus Bioinformatics Corporation 2017