Product Name: ERK5 (790-802)
Product Number: PE-01AXJ99
Size: | 200 µg | | Price: | 51.00 |
| 1 mg | | $US | 102.00 |
| 5 mg | | | 224.00 |
Peptide Name: ERK5 (790-802)
Product Use: Services as a blocking peptide for use with the ERK5-3 rabbit polyclonal antibody (Cat. No.: AB-NK206-5) that is also available from Kinexus. The peptide sequence is located in the pre-C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CADIESLQREIQMDSP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1834.03 Da
Peptide Purity Percent after Synthesis and Purification: >95
Scientific Background: ERK5 (MAPK7) is a protein-serine/threonine kinase of the CMGC group and MAPK family. It is important in controlling a cell's proliferation, differentiation, and cell survival. Phosphorylation of T219 and Y221 by MEK5 (MAP2K5) increases the phosphotransferase activity of ERK5. MEK5 is activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF). ERK5 may be a tumour requiring protein (TRP). Although there has been no direct linkage of ERK5 to formation of carcinomas in humans in vivo, in vitro ERK5 over-expression has been shown to increase metastasis, and ERK5 inhibition has been shown to inhibit osteosarcoma cell motility. Upregulation of the MEK5 gene has been noted in breast, prostate, and liver cancer.