Product Name: JNK2 (372-386)
Product Number: PE-01AXO99
Size: 200 µg      Price:51.00
1 mg      $US102.00
5 mg      224.00
Peptide Name: JNK2 (372-386)

Product Use: Services as a blocking peptide for use with the JNK2-2 rabbit polyclonal antibody (Cat. No.: AB-NK189-3) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: CVKDQPSDAAVSSNAT

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1591.68 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: JNK2 pan-specific antibody (Cat. No.: AB-NK189-3)

Scientific Background: JNK2 (MAPK9) is a protein-serine/threonine kinase of the CMGC group and MAPK family. It is involved in the control of cell differentiation, transformation, migration, proliferation, and programmed cell death in response to stress and cytokines. It has also been implicated in preventing ubiquitination of p53.Phosphorylation of T183 and Y185 by either of two dual specificity kinases, MAP2K4 and MAP2K7, increases phosphotransferase activity. Phosphorylation of S129 also increases phosphotransferase activity. It is nhibited by dual specificity phosphatases, such as DUSP1, which target the T183 and Y185 activatory phosphorylation sites. JNK2 has been shown, in a cancer cell line to have a role in breast cancer cell motility.