Product Name: WNK1 (207-221)
Product Number: PE-01AYZ90
Size: 200 µg      Price:45.00
1 mg      $US90.00
5 mg      211.00
Peptide Name: WNK1 (207-221)

Product Use: Services as a blocking peptide for use with the WNK1-2 rabbit polyclonal antibody (Cat. No.: AB-NK252-2) that is also available from Kinexus.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens


Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 1740 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: WNK1 pan-specific antibody (Cat. No.: AB-NK252-2)

Scientific Background: Wnk1 (PRKWNK1) is a protein-serine/threonine kinase of the Other group and Wnk family. It is involved in electrolyte homeostasis, cell survival, cell signalling, and cell proliferation. It is activated by hypertonicity. The activation requires autophosphorylation of S382. Phosphorylation of S378 also promotes increased phosphotransferase activity. Wnk1 can activate sodium-coupled chloride cotransporters, and inhibit potassium-coupled chloride cotransporters. Proteins activated by Wnk1 include SCNN1A, SCNN1B, SCNN1D and SGK1 while an inhibited protein is Wnk4 (via phosphorylation of Wnk4 or an associated complex of a Wnk1 autoinhibitory domain bound to Wnk4). Wnk4 inhibition could modulate, via phosphorylation, a thiazide-sensitive NaCl cotransporter transporter (specifically SLC12A3). Wnk1 has also been proposed to modulate NEDD4L phosphorylation, and have an effect on actin cytoskeleton rearrangement. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.