Product Name: SHIP1 (457-471)
Product Number: PE-01BBP99
| Size: | 200 µg | Price: | 51.00 | |
| 1 mg | $US | 102.00 | ||
| 5 mg | 224.00 |
Peptide Name: SHIP1 (457-471)
Product Use: Services as a blocking peptide for use with the SHIP1-1 rabbit polyclonal antibody (Cat. No.: AB-NP044-1) that is also available from Kinexus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CSEKEWLEILKHSLQE
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1971.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Product Use: Services as a blocking peptide for use with the SHIP1-1 rabbit polyclonal antibody (Cat. No.: AB-NP044-1) that is also available from Kinexus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CSEKEWLEILKHSLQE
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1971.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SHIP1 pan-specific antibody (Cat. No.: AB-NP044-1)
Storage Conditions: -20°C
Related Product 1: SHIP1 pan-specific antibody (Cat. No.: AB-NP044-1)
Scientific Background: SHIP1 (INPP5D) is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, to negatively regulate PI3K (phosphoinositide 3-kinase) pathways. It acts as a negative regulator of B-cell antigen receptor signalling, and mediates signalling from the FC-gamma-RIIB receptor (FCGR2B) as well as a negative regulator of myeloid cell proliferation/survival and chemotaxis, neutrophil migration, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signalling in platelets and JNK signalling in B-cells. It regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. It may also hydrolyze PtdIns(1,3,4,5)P4.
© Kinexus Bioinformatics Corporation 2017