Product Name: DMPK1 (407-425)
Product Number: PE-01BCR70
Size: 200 µg      Price:14.00
1 mg      $US27.00
5 mg      74.00
Peptide Name: DMPK1 (407-425)

Product Use: Services as a blocking peptide for use with the DMPK1-AKCD rabbit polyclonal antibody (Cat. No.: AB-NK264-1) that is also available from Kinexus. The peptide sequence is located just after kinase catalytic domain.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: CMALRDSEVPGPTPMELEA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Amide

Peptide Molecular Mass Calculated: 2045.3 Da

Peptide Purity Percent after Synthesis and Purification: >50

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: DMPK1 pan-specific antibody (Cat. No.: AB-NK264-1)

Scientific Background: DMPK1 is a protein-serine/threonine kinase of the AGC group and DMPK family. It is a protein kinase that is essential for maintaining skeletal muscle structure and function. It is activated in response to G protein second messengers. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. Phosphorylation by Raf1 may result in activation of DMPK. It is maintained in an inactive conformation by the negative autoregulatory C-terminal coiled-coil region.