Product Name: MRCKa (408-427)
Product Number: PE-01BED70
| Size: | 200 µg | Price: | 14.00 | |
| 1 mg | $US | 29.00 | ||
| 5 mg | 78.00 |
Peptide Name: MRCKa (408-427)
Product Use: Services as a blocking peptide for use with the MRCKa-AKCD rabbit polyclonal antibody (Cat. No.: AB-NK282-1) that is also available from Kinexus. The peptide sequence is located right after the kinase catalytic domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CVLSDRSSLRVTAGPTSLDL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2089.4 Da
Peptide Purity Percent after Synthesis and Purification: >50
Product Use: Services as a blocking peptide for use with the MRCKa-AKCD rabbit polyclonal antibody (Cat. No.: AB-NK282-1) that is also available from Kinexus. The peptide sequence is located right after the kinase catalytic domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CVLSDRSSLRVTAGPTSLDL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2089.4 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MRCKa pan-specific antibody (Cat. No.: AB-NK282-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MRCKa pan-specific antibody (Cat. No.: AB-NK282-1)
Scientific Background: MRCK-a (CDC42BPA, CDC42-binding protein kinase A) is a protein-serine/threonine kinase of the AGC group and DMPK family. It is a critical downstream effector and plays a role in the regulation of cytoskeleton remodelling and cell migration. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. MRCK-a is maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region.
© Kinexus Bioinformatics Corporation 2017