Product Name: PFTAIRE1 (10-28)
Product Number: PE-01BEN70
| Size: | 200 µg | Price: | 14.00 | |
| 1 mg | $US | 29.00 | ||
| 5 mg | 78.00 |
Peptide Name: PFTAIRE1 (10-28)
Product Use: Services as a blocking peptide for use with the PFTAIRE1-ANT rabbit polyclonal antibody (Cat. No.: AB-NK287-1) that is also available from Kinexus. The peptide sequence is located in the post-N-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAEKIGKMKKLRRTLSESFS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2311.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Product Use: Services as a blocking peptide for use with the PFTAIRE1-ANT rabbit polyclonal antibody (Cat. No.: AB-NK287-1) that is also available from Kinexus. The peptide sequence is located in the post-N-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAEKIGKMKKLRRTLSESFS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2311.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PFTAIRE1 pan-specific antibody (Cat. No.: AB-NK287-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PFTAIRE1 pan-specific antibody (Cat. No.: AB-NK287-1)
Scientific Background: PFTAIRE1 (CDK14, PFTK1) is a protein-serine/threonine kinase of the CMGC group and CDK family. It is expressed primarily in the postnatal and adult nervous system, and regulates cycle progression and cell proliferation. It is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. Its phosphotransferase activity is stimulated by association with cyclins CCDN3 and CCNY. It binds to 14-3-3 isoforms when it is phosphorylated at S119, which can be enhanced by CCNY. It is repressed by CDKN1A. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis. Positive expression of PFTAIRE1 when compared to its negative expression predicts resistance to chemotherapy and poorer prognosis in patients with oesophageal squamous cell carcinomas over a 5-year period.
© Kinexus Bioinformatics Corporation 2017