Product Name: H-Ras (58-64)
Product Number: PE-01BFV95
Size: 200 µg      Price:29.00
1 mg      $US59.00
5 mg      129.00
Peptide Name: H-Ras (58-64)

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: TAGQEEY

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 970.4 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: H-Ras is a small monomeric G protein that binds GDP/GTP and possess intrinsic GTPase activity. It alternates between an inactive form bound to GDP and an active form bound to GTP. It is normally activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). Mutations that compromise the GTPase activity of H-Ras (e.g. at G12) produce constitutively active, oncogenic forms of the protein, which commonly arise in human cancers.