Product Name: Flt1 (318-332)
Product Number: PE-01BGC86
| Size: | 200 µg | Price: | 38.00 | |
| 1 mg | $US | 77.00 | ||
| 5 mg | 166.00 |
Peptide Name: Flt1 (318-332)
Product Use: Services as a blocking peptide for use with the VEGFR1-2 rabbit polyclonal antibody (Cat. No.: AB-NK226-1) that is also available from Kinexus. The peptide sequence is located at the end of the third Ig-like C2-type domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CSFKSVNTSVHIYDKA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1798 Da
Peptide Purity Percent after Synthesis and Purification: >80
Product Use: Services as a blocking peptide for use with the VEGFR1-2 rabbit polyclonal antibody (Cat. No.: AB-NK226-1) that is also available from Kinexus. The peptide sequence is located at the end of the third Ig-like C2-type domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CSFKSVNTSVHIYDKA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 1798 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Flt1 pan-specific antibody (Cat. No.: AB-NK226-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Flt1 pan-specific antibody (Cat. No.: AB-NK226-1)
Scientific Background: VEGFR1 (Flt1) is a protein-tyrosine kinase of the TK group and VEGFR family. It functions as a membrane receptor for VEGFA, VEGFB, and PGF. Binding vascular endothelial growth factor (VEGF), which induces dimerization and autophosphorylation. Autophosphorylation of Y1169 induces interaction with PLCg1. Autophosphorylation of Y1213 increases phosphotransferase activity and induces interaction with Grb2, PLCg1 and SHP2. Autophosphorylation ofY1333 induces interaction with Cbl, Crk, Nck1 and PLCg1. VEGFR1 is critical for the development of embryonic vasculature, angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. In adulthood, VEGFR1 promotes endothelial cell proliferation, survival, and angiogenesis. In addition, the VEGFR1 protein mediates the activation of the MAPK and Akt1 intracellular signalling pathways, as well as directly phosphorylates Src, Yes1, and possibly Cbl. VEGFR1 appears to be an oncoprotein (OP). Cancer-related mutations in human tumours point to a gain of function of the protein kinase. Gain-of-function mutations in the VEGFR1 gene are associated with cancer development. VEGFR1 expression has been shown to contribute to cancer cell survival, proliferation, migration, tissue invasion, tumour angiogenesis, and metastasis. In addition, VEGFR1 may promote cancer pathogenesis by enhancing inflammatory responses and recruiting tumour-infiltrating macrophages.
© Kinexus Bioinformatics Corporation 2017