Product Name: Alk1Subtide
Product Number: PE-01BGG99
Size: 200 µg      Price:36.00
1 mg      $US72.00
5 mg      157.00
Peptide Name: Alk1Subtide

Product Use: For assaying the phosphotransferase activity of Serine/threonine-protein kinase receptor R3 (UniProt ID P37023).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: RGRRKSFRG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1293.7 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid
Storage Conditions: -20°C

Peptide Recommended Enzyme: Alk1

Scientific Background: Alk1 is one of several protein kinases that can phosphorylate KinSub5RRKSF. Human Alk1 is a protein-serine/threonine kinase of 503 amino acid length, with a predicted molecular mass of 56,124 Da. It is a member of the TKL group of protein kinases in the STKR family, and Type1 subfamily. This kinase is highly expressed and widely distributed in most tested human tissues. Orthologues of Alk1 are highly conserved in mammals and birds. Alk1 functions as a TGF-beta type I receptor (1). It is activated by binding activin, which induces heterodimerization and autophosphorylation. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with Alk1 and mediate TGF-beta signaling. Northern blot and RT-PCR analysis show that Alk1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. Alk1 has been linked with the development of Hereditary Hemorrhagic Telangiectasia Type 2 (HHT2). Alk1 expression in inflammatory myofibroblastic tumours of the urinary bladder have also been reported (2).