Product Name: CAMK1Subtide
Product Number: PE-01BGM99
Size: 200 µg      Price:45.00
1 mg      $US91.00
5 mg      199.00
Peptide Name: CAMK1Subtide

Product Use: For assaying the phosphotransferase activity of calcium/calmodulin-dependent protein-serine kinase 1 alpha (UniProt ID Q14012).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: GLRRRKSERNLG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1616.1 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid
Storage Conditions: -20°C

Peptide Recommended Enzyme: CAMK1

Scientific Background: CaMK1a is a protein-serine/threonine kinase of the CAMK group and CAMK1 family. Phosphorylation at Thr-177 increases its phosphotransferase activity by approximately 25-fold in a Ca(2+)-CaM dependent manner. Thr-177 is phosphorylated by CAMKK1 or CAMKK2. CaMK1a and CaMKK1 regulate the G(O)-G(1) restriction check point for cell cycle transition in human breast cancer cells. Target substrates for CaMK1a includes CREB1, ATF1, CFTR, MYL9, and SYN1/synapsin I.