Product Name: DAPKSubtide
Product Number: PE-01BGZ95
Size: 200 µg      Price:42.00
1 mg      $US84.00
5 mg      185.00
Peptide Name: DAPKSubtide

Product Use: For assaying the phosphotransferase activity of Death-associated protein kinase 3 (UniProt ID O43293).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: KRKRAKTFRVA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1534.87 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Peptide Recommended Enzyme: DAPK

Scientific Background: DAPK3 (also known as ZIP) is a protein-serine/threonine kinase that is a member of the CAMK group of protein kinases in the DAPK family. This kinase is moderate to highly expressed in most tested human tissues. Orthologues of DAPK3 are highly conserved in animals and plants. DAPK3 is activated by phosphorylation at T180, T225, and T265. Homodimers of DAPK3 or heterodimers with ATF4 formed via a leucine zipper domain is required for full enzymatic activity. DAPK3 plays a role in apoptosis. It phosphorylates core histones H3 and H4, and myosin light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4.