Product Name: EphSubtide
Product Number: PE-01BHF95
| Size: | 200 µg | Price: | 45.00 | |
| 1 mg | $US | 91.00 | ||
| 5 mg | 199.00 |
Peptide Name: EphSubtide
Product Use: For assaying the phosphotransferase activity of Ephrin type-B receptor 1 protein-tyrosine kinase (UniProt ID P54762).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KRLEDDDYVNVG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1596.67 Da
Peptide Purity Percent after Synthesis and Purification: ~95
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: For assaying the phosphotransferase activity of Ephrin type-B receptor 1 protein-tyrosine kinase (UniProt ID P54762).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KRLEDDDYVNVG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1596.67 Da
Peptide Purity Percent after Synthesis and Purification: ~95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Eph
Peptide Recommended Enzyme: Eph
Scientific Background: EphB1 is a protein-tyrosine kinase of the TK group and Eph family. It is a receptor kinase that mediates cell contact signalling via binding Ephrin B family (EFNB1, EFNB2 and EFNB3) of ligands. Phosphorylation at Y594 induces interaction with Nck1 and the SH2 domain of Grb10. Phosphorylation at Y928 induces interaction with Grb2 and Grb7. Interaction with Shc1 and Src involves Y600 phosphorylation, and Shc1binding also occurs with Y778 phosphorylation. EphB1controls neuronal cell development through mediating axon guidance. It also controls chemotaxis, proliferation, and polarity of hippocampal neuronal progenitor cells. The SH2 domain of GRB10 cannot bind EphB1 with an Y928F mutation. EphB1 has been linked with the development of gastric adenocarcinomas and ovarian undifferentiated carcinoma.
© Kinexus Bioinformatics Corporation 2017