Product Name: GrkSubtide
Product Number: PE-01BHM85
| Size: | 200 µg | Price: | 39.00 | |
| 1 mg | $US | 78.00 | ||
| 5 mg | 168.00 |
Peptide Name: GrkSubtide
Product Use: For assaying the phosphotransferase activity of Beta-adrenergic receptor kinase 1 (UniProt ID P25098).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEEDEETENQQG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1794.75 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: For assaying the phosphotransferase activity of Beta-adrenergic receptor kinase 1 (UniProt ID P25098).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEEDEETENQQG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1794.75 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: GRK
Peptide Recommended Enzyme: GRK
Scientific Background: GRK2 (also known as beta-adrenergic receptor kinase 1) is a member of the AGC group of protein kinases in the GRK family, and BARK subfamily. This kinase is highly expressed and widely distributed in most tested human tissues. Orthologues of GRK2 are highly conserved in vertebrates, including amphibians. It is activated by binding a Gbeta/gamma subunit complex. Phosphorylation of S29 increases its phosphotransferase activity. It specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. It is a key regulator of LPAR1 signalling, by competing with RALA for binding to LPAR1. It desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
© Kinexus Bioinformatics Corporation 2017