Product Name: GRK1Subtide
Product Number: PE-01BIG95
Size: 200 µg      Price:58.00
1 mg      $US116.00
5 mg      255.00
Peptide Name: GRK1Subtide

Product Use: For assaying the phosphotransferase activity of Rhodopsin kinase (UniProt ID Q15835).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: KKADAKAFATVVAVVA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1762.11 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Peptide Recommended Enzyme: GRK1

Scientific Background: RHOK (GRK1) is protein-serine/threonine kinase in the ACG family and GRK group, and GRK subfamily. It is a retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein-coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. It is inhibited by phosphorylation of S21.