Product Name: TBK1Subtide
Product Number: PE-01BJO90
Size: 200 µg      Price:45.00
1 mg      $US91.00
5 mg      214.00
Peptide Name: TBK1Subtide

Product Use: For assaying the phosphotransferase activity of TANK binding kinase TBK1; Serine/threonine-protein kinase TBK1 (UniProt ID Q9UHD2).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: RRHLGQLSLDLPLA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1762.1 Da

Peptide Purity Percent after Synthesis and Purification: 90

Peptide Appearance: White powder

Peptide Form: Solid
Storage Conditions: -20°C

Peptide Recommended Enzyme: TBK1

Scientific Background: TBK1 (NAK) is a protein-serine/threonine kinase of the Other group and IKK family. It plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. To establish such an antiviral state. It mediates the immune response via signalling with TANK, TRAF3, IRF3, IRF7, and DDX3X. It can act as a scaffold for the proteins FADD, AZI2, MAVS, TRADD, TANK or TBKBP1/SINTBAD. TBK1 can be ubiquitinated at K30 and K401. TBK1 is phosphorylated and activated at S172A, Y325, and Y577. It can phosphorylate NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. It phosphorylates and activates AKT1.