Product Name: CREB1 (83-95) pS89+pS93 (CREBtide-P2), biotinyl
Product Number: PE-03AAJ95
| Size: | 200 µg | Price: | 75.00 | |
| 1 mg | $US | 150.00 |
Peptide Name: CREB1 (83-95) pS89+pS93 (CREBtide-P2), biotinyl
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRREIL-pS-RRP-pS-YRG
Peptide Modifications N Terminus: Biotin-βAla
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2230.35 Da
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KRREIL-pS-RRP-pS-YRG
Peptide Modifications N Terminus: Biotin-βAla
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2230.35 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation (1). Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons (2). CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression.
© Kinexus Bioinformatics Corporation 2017