Product Name: Cofilin 1 (137-143) pY140
Product Number: PE-04ACO95
| Size: | 200 µg | Price: | 41.00 | |
| 1 mg | $US | 82.00 |
Peptide Name: Cofilin 1 (137-143) pY140
Product Use: Services as a blocking peptide for use with the Cofilin 1-pY140 rabbit polyclonal antibody (Cat. No.: AB-PN506) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located near the end of the Cofilin_ADF domain. This is the major in vivo phosphorylation site in Cofilin 1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ANC-pY-EEV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the Cofilin 1-pY140 rabbit polyclonal antibody (Cat. No.: AB-PN506) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located near the end of the Cofilin_ADF domain. This is the major in vivo phosphorylation site in Cofilin 1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ANC-pY-EEV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1081.04 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Cofilin 1 - pY140 phosphosite-specific antibody (Cat. No.: AB-PN506)
Peptide Molecular Mass Calculated: 1081.04 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Cofilin 1 - pY140 phosphosite-specific antibody (Cat. No.: AB-PN506)
Scientific Background: Cofilin 1 interacts with F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics, and is important for normal progress through mitosis and normal cytokinesis. It plays a role in the regulation of cell morphology and cytoskeletal organization. It is required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, which increases its efficiency in chemokine uptake and degradation.
© Kinexus Bioinformatics Corporation 2017