Product Name: Pyk2 (577-583) pY579+pY580
Product Number: PE-04ADL99
| Size: | 200 µg | Price: | 71.00 | |
| 1 mg | $US | 142.00 | ||
| 5 mg | 311.00 |
Peptide Name: Pyk2 (577-583) pY579+pY580
Product Use: Services as a blocking peptide for use with the PYK2-pY579+pY580 rabbit polyclonal antibody (Cat. No.: AB-PK789) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y579 and Y580 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ED-pY-pY-KAS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the PYK2-pY579+pY580 rabbit polyclonal antibody (Cat. No.: AB-PK789) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y579 and Y580 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ED-pY-pY-KAS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1209.04 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Pyk2 - pY579+pY580 phosphosite-specific antibody (Cat. No.: AB-PK789)
Peptide Molecular Mass Calculated: 1209.04 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Pyk2 - pY579+pY580 phosphosite-specific antibody (Cat. No.: AB-PK789)
Scientific Background: Pyk2 (PTK2B, FAK2) is a protein-tyrosine kinase of the TK group and Fak family. It is a non-receptor kinase that has a role in actin cytoskeleton rearrangement, cell migration, cell polarization, adhesion, bone remodeling, and controlling amount of marginal B-cells' migration and presence in the spleen. Phosphorylation at TY402 increases phosphotransferase activity and induces interaction with ErbB2, RasGAP and Src. Phosphorylation at Y579 increases its phosphotransferase activity. NPHP1 interaction with Pyk2 has been interrupted with a P859A mutation. A phosphorylation site of Pyk2 can be inhibited with an Y881F mutation, which will also impair GRB2 interaction.
© Kinexus Bioinformatics Corporation 2017