Product Name: p38b (177-182) pT180+pY182
Product Number: PE-04ADT80
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 95.00 | ||
| 5 mg | 205.00 |
Peptide Name: p38b (177-182) pT180+pY182
Product Use: Services as a blocking peptide for use with the p38b-pT180+pY182 rabbit polyclonal antibody (Cat. No.: AB-PK741) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T180 and Y182 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EEM-pT-G-pY
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the p38b-pT180+pY182 rabbit polyclonal antibody (Cat. No.: AB-PK741) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T180 and Y182 phosphorylation are predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EEM-pT-G-pY
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1062.92 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: p38b - pT180+pY182 phosphosite-specific antibody (Cat. No.: AB-PK741)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1062.92 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: p38b - pT180+pY182 phosphosite-specific antibody (Cat. No.: AB-PK741)
Scientific Background: p38b (MAPK11) is a protein-serine/threonine kinase that is a member of the CMGC group of protein kinases in the MAPK family, and p38 subfamily. This kinase is moderate to highly expressed in most tested human tissues. p38b is activated by both proinflammatory cytokines and environmental stress. p38b is directly activated by phosphorylation at Y182 and probably T180 by MKK6 (MAP2K6, MEK6). Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. Alternatively spliced transcript variants encoding the same protein have been observed. p38b has been linked with the development of inflammation and autoimmunity, diabetes and lung neuroendocrine carcinomas. Some of the targets of p38b, like p38a, are downstream kinases such as MSK1 (RPS6KA5) and MSK2 (RPS6KA4), which play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery.Two other kinase targets, MAPKAPK2 (MK2) and MAPKAPK3 (MK3), participate in the control of gene expression mostly at the post-transcriptional level. MKNK1/MNK1 and MKNK2/MNK2 are two other p38-activated protein kinases that regulate protein synthesis. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPK, including ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53, MEF2C and MEF2A.
© Kinexus Bioinformatics Corporation 2017