Product Name: STAM2 (371-377) pY374
Product Number: PE-04AEF95
Size: | 200 µg | | Price: | 47.00 |
| 1 mg | | $US | 94.00 |
| 5 mg | | | 206.00 |
Peptide Name: STAM2 (371-377) pY374
Product Use: Services as a blocking peptide for use with the STAM2-pY374 rabbit polyclonal antibody (Cat. No.: AB-PN538) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminal half of the protein. This is the second major in vivo phosphorylation site in STAM2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: YSV-pY-SKL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Scientific Background: STAM2 (STAMP2) is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signalling leading to DNA synthesis and MYC induction. It may also play a role in T-cell development, and appears to be involved in down-regulation of receptor-tyrosine kinases via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex).