Product Name: SHIP2 (883-889) pY886
Product Number: PE-04AES99
Size: | 200 µg | | Price: | 47.00 |
| 1 mg | | $US | 94.00 |
| 5 mg | | | 206.00 |
Peptide Name: SHIP2 (883-889) pY886
Product Use: Services as a blocking peptide for use with the SHIP2-pY886 rabbit polyclonal antibody (Cat. No.: AB-PN534) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the Exo-endo_phos and SHAM_1 domains. This is one of the main in vivo phosphorylation sites in proteins. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ERL-pY-EWI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Scientific Background: SHIP2 is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, and negatively regulate the PI3K (phosphoinositide 3-kinase) pathways.