Product Name: SHIP2 (883-889) pY886
Product Number: PE-04AES99
Size: 200 µg      Price:47.00
1 mg      $US94.00
5 mg      206.00
Peptide Name: SHIP2 (883-889) pY886

Product Use: Services as a blocking peptide for use with the SHIP2-pY886 rabbit polyclonal antibody (Cat. No.: AB-PN534) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the Exo-endo_phos and SHAM_1 domains. This is one of the main in vivo phosphorylation sites in proteins. The effect of its phosphorylation is unclear.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: ERL-pY-EWI

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 1261.33 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: SHIP2 - pY886 phosphosite-specific antibody (Cat. No.: AB-PN534)

Scientific Background: SHIP2 is a phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, and negatively regulate the PI3K (phosphoinositide 3-kinase) pathways.