Product Name: HGS (213-219) pY216
Product Number: PE-04AFB95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: HGS (213-219) pY216
Product Use: Services as a blocking peptide for use with the HGS-pY216 rabbit polyclonal antibody (Cat. No.: AB-PN519) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the FYVE domain. This is the major in vivo phosphorylation site in HGS. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EPC-pY-EQL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the HGS-pY216 rabbit polyclonal antibody (Cat. No.: AB-PN519) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the FYVE domain. This is the major in vivo phosphorylation site in HGS. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EPC-pY-EQL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1134.16 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: HGS - pY216 phosphosite-specific antibody (Cat. No.: AB-PN519)
Peptide Molecular Mass Calculated: 1134.16 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: HGS - pY216 phosphosite-specific antibody (Cat. No.: AB-PN519)
Scientific Background: HGS mediates intracellular signal transduction from cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It has been implicated as a direct effector of PI3-kinase in vesicular pathway via early endosomes, regulating trafficking to early and late endosomes by recruiting clathrin, concentrating ubiquitinated receptors within clathrin-coated regions, and down-regulating receptor-tyrosine kinases via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex.
© Kinexus Bioinformatics Corporation 2017