Product Name: ErbB3 (1286-1292) pY1289
Product Number: PE-04AGZ95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: ErbB3 (1286-1292) pY1289
Product Use: Services as a blocking peptide for use with the ErbB3-pY1289 rabbit polyclonal antibody (Cat. No.: AB-PK616) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the cytoplasmic region of ErbB3 near the C-terminus after the kinase catalytic domain. This is the major in vivo phosphorylation sites in ErbB3. Phosphorylation Phosphorylation induces interaction with PIK3R2 and regulates carcinogenesis, and cell growth.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EQG-pY-EEM
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the ErbB3-pY1289 rabbit polyclonal antibody (Cat. No.: AB-PK616) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the cytoplasmic region of ErbB3 near the C-terminus after the kinase catalytic domain. This is the major in vivo phosphorylation sites in ErbB3. Phosphorylation Phosphorylation induces interaction with PIK3R2 and regulates carcinogenesis, and cell growth.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EQG-pY-EEM
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1139.08 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ErbB3 - pY1289 phosphosite-specific antibody (Cat. No.: AB-PK616)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1139.08 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ErbB3 - pY1289 phosphosite-specific antibody (Cat. No.: AB-PK616)
Scientific Background: ErbB3 (HER3) is a protein-tyrosine kinase of the TK group and EGFR family. It is a receptor kinase that bind and be activated by NTAK and neuregulins. It has been proposed to be deficient in phosphotransferase activity. While the kinase domain appararently lacks activity but heterodimerizes with other EGFRs permits transduction of growth signals. Phosphorylation of Y1222 and Y1260 induces interaction with PIK3C and PIK3R1. ErbB3 appears to be up-regulated in many cancer, including medulloblastomas, verrucous carcinomas, childhood medulloblastomas, carotid body tumours (CBT), and gestational trophoblastic tumours (GTD).
© Kinexus Bioinformatics Corporation 2017