Product Name: PI3KR1 (464-470) pY467
Product Number: PE-04AHI99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: PI3KR1 (464-470) pY467
Product Use: Services as a blocking peptide for use with the PIK3R1-pY467 rabbit polyclonal antibody (Cat. No.: AB-PN526) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the two SH2 domains in the C-terminus half of the protein. This is the major in vivo phosphorylation site in PI3KR1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DRL-pY-EEY
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the PIK3R1-pY467 rabbit polyclonal antibody (Cat. No.: AB-PN526) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the two SH2 domains in the C-terminus half of the protein. This is the major in vivo phosphorylation site in PI3KR1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DRL-pY-EEY
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1241.19 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PI3KR1 - pY467 phosphosite-specific antibody (Cat. No.: AB-PN526)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1241.19 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PI3KR1 - pY467 phosphosite-specific antibody (Cat. No.: AB-PN526)
Scientific Background: PIK3R1 binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. It also mediates cellular signalling in response to various growth factors that bind to other receptor-tyrosine kinases, including EGF, IGF1, VEGFA and PDGF, as well as downstream proteins such as insulin-receptor substrate (IRS) proteins. It plays a role in ITGB2 signalling (PubMed:17626883, PubMed:19805105, PubMed:7518429), and modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver to improve glucose tolerance (PubMed:20348923).
© Kinexus Bioinformatics Corporation 2017