Product Name: Yes (219-226) pY222+pY223
Product Number: PE-04AHY99
| Size: | 200 µg | Price: | 74.00 | |
| 1 mg | $US | 148.00 | ||
| 5 mg | 325.00 |
Peptide Name: Yes (219-226) pY222+pY223
Product Use: Services as a blocking peptide for use with the Yes-pY222+pY223 rabbit polyclonal antibody (Cat. No.: AB-PK858) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the SH2 domain. One of the two major in vivo phosphorylation sites in Yes. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NGG-pY-pY-ITT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the Yes-pY222+pY223 rabbit polyclonal antibody (Cat. No.: AB-PK858) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the SH2 domain. One of the two major in vivo phosphorylation sites in Yes. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NGG-pY-pY-ITT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1221.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Yes - pY222+pY223 phosphosite-specific antibody (Cat. No.: AB-PK858)
Peptide Molecular Mass Calculated: 1221.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Yes - pY222+pY223 phosphosite-specific antibody (Cat. No.: AB-PK858)
Scientific Background: Yes (Yes1) is a protein-tyrosine kinase of the TK group and Src family. It promotes G2/M cell cycle progression and cytokinesis. Y426F mutation in Yes leads to about half loss of CSK-mediated inhibition. Yes may be an oncoprotein (OP) based on its similarity to other Src family protein-tyrosine kinases. It is the cellular homologue of the Yamaguchi sarcoma virus oncoprotein. By isotopic in situ hybridization, Yes1 gene localization is frequently associated with chromosome translocation and pathogenesis of follicular lymphoma.
© Kinexus Bioinformatics Corporation 2017