Product Name: CLK1 (334-340) pS337
Product Number: PE-04AKA95
Size: 200 µg      Price:42.00
1 mg      $US84.00
5 mg      185.00
Peptide Name: CLK1 (334-340) pS337

Product Use: Services as a blocking peptide for use with the CLK1-pS337 rabbit polyclonal antibody (Cat. No.: AB-PK583) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S337 phosphorylation is predicted to be stimulatory for phosphotransferase activity.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: EHH-pS-TLV

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 1076.06 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Related Product 1: CLK1 - pS337 phosphosite-specific antibody (Cat. No.: AB-PK583)

Scientific Background: CLK1 is a protein-serine/threonine kinase of the CMGC group and CLK family. It is a dual-specificity kinase that phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may involve in regulatory mechanisms of RNA splicing. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK1, which could phosphorylates the specific SR proteins such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors. CLK1 interacts with PPIG. This kinase shows high variability in human tissue distribution with the highest levels detected in adrenals, brain, kidney, lung, ovary, pituitary, prostate, spinal cord, testes, thymus, thyroid, trachea, and uterus. Orthologues of CLK1 are amongst the most highly conserved protein kinases in animals, plants, fungi and unicellular eukaryotes.