Product Name: Fms (696-702) pY699
Product Number: PE-04AKD95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: Fms (696-702) pY699
Product Use: Services as a blocking peptide for use with the CSF1R-pY699 rabbit polyclonal antibody (Cat. No.: AB-PK587) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the kinase catallytic domain. This is the major in vivo phosphorylation site in CSF1R. Phosphorylation induces binding to PIK3CB and Grb2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GVD-pY-KNI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the CSF1R-pY699 rabbit polyclonal antibody (Cat. No.: AB-PK587) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the kinase catallytic domain. This is the major in vivo phosphorylation site in CSF1R. Phosphorylation induces binding to PIK3CB and Grb2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GVD-pY-KNI
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1062.06 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fms - pY699 phosphosite-specific antibody (Cat. No.: AB-PK587)
Peptide Molecular Mass Calculated: 1062.06 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Fms - pY699 phosphosite-specific antibody (Cat. No.: AB-PK587)
Scientific Background: CSF1R (Fms) is a member of the TK group of protein kinases in the PDGFR family. It acts as a membrane receptor for macrophage colony-stimulating factor 1 (CSF1) and IL34, and it functions in the regulation of cell survival, proliferation, and differentiation in hematopoietic precursor cells, specifically monocytes and macrophages. However, this kinase is highly expressed and widely distributed in most tested human tissues except in the brain and spinal cord, where it is more moderately expressed. Orthologues of CSF1R are highly conserved in mammals and birds. CSF1R contains a so-called kinase insert domain and is a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in CSF1R have been associated with providing sustained signals for cell growth and a predisposition to myeloid malignancy. CSF1R has been linked with the development of acute myeloid leukemia, chronic myelomonocytic leukemia, myelodysplasia, hepatocellular carcinomas, breast cancer, and lung squamous cell carcinomas (LSCC). Gain-of-function mutations in the Fms gene are associated with several forms of cancer.
© Kinexus Bioinformatics Corporation 2017